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Most strikingly, analysis of the relative abundance of these metabolites showed extracellular accumulation of several aromatic amino acids and weak acids (e.g., dicarboxylic acids, ketones/keto-acids, and hydroxy fatty acids) in the gsh2 mutant and a significantly depleted intracellular amino acid content (Fig

We analyzed development of HCC in 110594 patients with chronic hepatitis B or liver cirrhosis without a history of HCC in the past

In the recent Rome Proposal, a COPD exacerbation was described as an event characterised by an acute burst of airways inflammation due to stimuli (e.g., bacteria, viruses, or environmental pollutants) that is coupled with worsening of existing airflow limitation, leading to worsening symptoms (dyspnoea and/or cough and sputum), which may be accompanied by tachypnea and/or tachycardia [4]